Clinical Trial: Study to Compare Different Light Therapies (Narrowband Ultraviolet B vs PUVA) for Hand and Foot Skin Diseases.
Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional
Official Title: A Randomized Controlled Trial of Narrowband Ultraviolet B vs Topical Psoralen Plus Ultraviolet A Photochemotherapy for Hand and Foot Dermatoses
Brief Summary: Hand and foot skin diseases, such as dermatitis and psoriasis, that do not respond to topical creams can be treated with ultraviolet light therapy. Topical psoralen plus ultraviolet A (PUVA) is commonly used to treat these conditions, but requires additional time for the hands and feet to soak in psoralens before the light treatment. Newer narrowband ultraviolet B (NBUVB) units have become available which allow for light treatment without soaking first. The purpose of this study is to determine if NBUVB is as effective as PUVA for hand and foot skin diseases.
Detailed Summary:
Sponsor: Mayo Clinic
Current Primary Outcome: Number of treatments required to reach clearance [ Time Frame: Baseline to 15 months ]
Original Primary Outcome: Number of treatments required to reach clearance
Current Secondary Outcome:
- Change in symptom score (erythema, scaling/hyperkeratosis, papular/vesicular eruption, and fissures) [ Time Frame: Baseline to 15 months ]
- Change in global score [ Time Frame: Baseline to 15 months ]
- Number of patients reaching clearance [ Time Frame: Baseline to 15 months ]
- Adverse effects [ Time Frame: Baseline to 15 months ]
- Number of days in remission [ Time Frame: Baseline to 15 months ]
Original Secondary Outcome:
- Change in symptom score (erythema, scaling/hyperkeratosis, papular/vesicular eruption, and fissures)
- Change in global score
- Number of patients reaching clearance
- Adverse effects
- Number of days in remission
Information By: Mayo Clinic
Dates:
Date Received: September 14, 2005
Date Started: March 2005
Date Completion:
Last Updated: May 18, 2015
Last Verified: May 2015
