Clinical Trial: Association Between Asthma and Food Allergy

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Association Between Asthma and Food Allergy in Children and Adults

Brief Summary:

Prevalences of food allergies and asthma increased in the population during the last decades. These two pathologies, responsible for a real burden, are often associated and are to be considered as comorbidities; this aspect is more and more studied in the literature and many authors tried to find a link between diets and asthma. The narrow link between these two atopic pathologies and the fact that food allergy can come along with respiratory symptoms also in patients without history of asthma must be better understood, considered into the management of food allergy. The main objective of this study is to study the prevalence of signs and/or symptoms suggestive of bronchial hyperreactivity, during an oral food challenge (OFC) in patients older than 5 years. The secondary objective is to study the risk factors to develop asthma during a food allergy reaction.

This historical-prospective single center study , was realized in the Allergy Unit of the University Hospital of Montpellier. All the patients having been hospitalized for a positive OFC between January, 2001 and January, 2016 were included. The diagnosis of asthma was established according to the recommended international clinical and physiological criteria. Prevalence of bronchial hyperreactivity during OFC among those with positive OFC, was calculated. The search for risk factors was made by a logistic regression univariate then multivariate, completed by a decision tree.


Detailed Summary:
Sponsor: University Hospital, Montpellier

Current Primary Outcome: Number of patient with bronchospasm in OFC [ Time Frame: up to 3 hours ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Questionnaire for the assessment of the responsible food of allergy [ Time Frame: up to 3 hours ]
  • the eliciting dose [ Time Frame: up to 3 hours ]
    the dose of the tested food which elicits the symptoms of allergy
  • The grade of the allergic reaction shown during the last food ingestion of the concerned food [ Time Frame: up to 3 hours ]
  • The presence of one or several sensitisations associated with respiratory allergens [ Time Frame: up to 3 hours ]
    defining the atopic ground
  • The level of specific immunoglobulin E of the concerned food [ Time Frame: up to 3 hours ]
  • The time of appearance of the first signs of atopy [ Time Frame: up to 3 hours ]
  • questionnaire for the assessment of the mode of clinical expression of food allergies [ Time Frame: up to 3 hours ]


Original Secondary Outcome: Same as current

Information By: University Hospital, Montpellier

Dates:
Date Received: July 18, 2016
Date Started: March 2016
Date Completion: December 2017
Last Updated: August 25, 2016
Last Verified: August 2016