Clinical Trial: Impact of Staphylococcus Aureus on Folliculitis Decalvans

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Role of Staphylococcus Aureus on Folliculitis Decalvans. A Comparative Bacteriological Study.

Brief Summary:

The folliculitis decalvans (FD) is an orphan disease , common in consultation specialized on scalp. This disease is currently not curable, responsible for significant for patients. The pathophysiology is poorly understood, Staphylococcus aureus (SA) appears to play a role, never previously studied, and the study will attempt to clarify it.

Controversies in the literature on the pathophysiological hypotheses can be summed up as follows :

FD is it an infectious folliculitis where SA (almost always found on the lesions plays a direct role possibly aided by a lack of local immune protection , or is it a pustular inflammatory unknown cause where the SA has no direct role but is a cofactor or a simple germ superinfection.

Our study has plans to bring new evidence to help decide between these two opposite but not mutually exclusive concepts .


Detailed Summary:
Sponsor: Assistance Publique - Hôpitaux de Paris

Current Primary Outcome: presence of Staphylococcus Aureus in cutaneous biopsies (at least one colony) [ Time Frame: 1 day ]

The primary endpoint is the presence of Staphylococcus Aureus in cutaneous biopsies before any therapy and notably antibiotics.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • presence of Staphylococcus Aureus in cutaneous biopsies (at least one colony) after treatment [ Time Frame: 10 weeks ]
  • presence of Staphylococcus Aureus in nasal swab (at least one colony) [ Time Frame: 1 day ]


Original Secondary Outcome: Same as current

Information By: Assistance Publique - Hôpitaux de Paris

Dates:
Date Received: May 14, 2014
Date Started: March 2014
Date Completion:
Last Updated: June 23, 2016
Last Verified: March 2015