Clinical Trial: Pathophysiological Mechanisms of Fibromuscular Dysplasia
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Pathophysiological Mechanisms of Fibromuscular Dysplasia
Brief Summary: Fibromuscular dysplasia is an non inflammatory non atherosclerotic obstructive arterial disease affecting mid-size arteries. It is considered as a rare vascular disease of unknown origin. Fibromuscular dysplasia may become symptomatic depending on location and severity of narrowing of the arterial lumen. for example,when a stenosis develops within a renal artery, arterial hypertension may develop. The cause of fibromuscular dysplasia is unknown. Several factors have been suggested to be associated with it: tobacco abuse or oestrogens. In order to progress into identifying possible causative mechanisms of the disease, we design a pathophysiology study destined to assess endothelial function in patients with fibromuscular dysplasia and to identify possible plasmatic biomarkers of the disease.
Detailed Summary:
Sponsor: Assistance Publique - Hôpitaux de Paris
Current Primary Outcome: Comparison of circulating microparticles of patients vs. fibromuscular dysplasia with age and sex matched healthy volunteers and hypertensive patients [ Time Frame: Once within 15 days ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Comparison of circulating micro RNAs (miR-143 ; miR-145) between the 3 arms [ Time Frame: Once within 15 days ]
- Comparison of matrixmetalloproteases between the 3 arms [ Time Frame: Once within 15 days ]
- Comparison of c-reactive protein between the 3 arms [ Time Frame: Once within 15 days ]
- Comparison of PLA2 between the 3 arms [ Time Frame: Once within 15 days ]
- Comparison of endothelium dependant vasodilation between the 3 arms [ Time Frame: Once within 15 days ]
- Comparison of endothelium independent vasodilation between the 3 arms [ Time Frame: Once within 15 days ]
- Comparison of pulse wave velocity between the 3 arms [ Time Frame: Once within 15 days ]
Original Secondary Outcome: Same as current
Information By: Assistance Publique - Hôpitaux de Paris
Dates:
Date Received: September 2, 2013
Date Started: November 2011
Date Completion:
Last Updated: October 17, 2016
Last Verified: October 2016