Clinical Trial: Impact of the PET in the Diagnosis Strategy of FUO or Inflammatory Syndrome in Immunocompetent Patients FUO-TEP

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Impact of the PET-scan in the Diagnosis Strategy of Fever Unknown Origin or Inflammatory Syndrome in Immunocompetent Patients

Brief Summary: Fever of unknown origin (FUO) and chronic inflammatory syndrome could be seen in many affections. The diagnostic process is still a challenge and could not be specified yet after several clinical studies performed by trained teams using two levels diagnostic procedures. For this reason, the diagnosis involves many additional and expensive tests such as computed tomography (CT scan), scintigraphic imaging, endoscopy, biopsy. There is no evidence-based recommendation for the diagnostic work-up of FUO or chronic inflammatory syndrome. Positron emission tomography with 2-[18F] fluoro-2-deoxy-D-glucose combined with CT scan (FDG-PET/CT) is widely used in malignant diseases and seems to be promising for the diagnosis of inflammatory disorders. Its role has not been yet clearly defined in the investigation of FUO and chronic inflammatory syndrome.

Detailed Summary:

All patients with FUO and chronic inflammatory syndrome will undergo FDG-PET/CT and conventional morphologic imaging modalities. Results of these two diagnostic procedures in identifying diagnostic clues will be compared.

We assume FDG-PET/CT could be safer and more helpful to reach early final diagnosis in patients with FUO and chronic inflammatory syndrome than conventional morphologic imaging modalities


Sponsor: University Hospital, Limoges

Current Primary Outcome: To assess the contribution of FDG-PET/CT in the early diagnostic work-up of patients with FUO or chronic inflammatory syndrome [ Time Frame: 3 month ]

Original Primary Outcome: To assess the contribution of FDG-PET/CT in the early diagnostic work-up of patients with FUO or chronic inflammatory syndrome

Current Secondary Outcome:

  • To establish the role of FGD PET in reaching final diagnosis compared to conventional morphologic imaging modalities including computer tomography and gallium-67 citrate scintigraphy. [ Time Frame: 3 months ]
  • To evaluate sensitivity and specificity of this diagnostic procedure [ Time Frame: 3 months ]
  • To analyse the cost effectiveness of this diagnostic approach [ Time Frame: 3 months ]


Original Secondary Outcome:

  • To establish the role of FGD PET in reaching final diagnosis compared to conventional morphologic imaging modalities including computer tomography and gallium-67 citrate scintigraphy.
  • To evaluate sensitivity and specificity of this diagnostic procedure
  • To analyse the cost effectiveness of this diagnostic approach


Information By: University Hospital, Limoges

Dates:
Date Received: September 10, 2010
Date Started: May 2008
Date Completion:
Last Updated: February 17, 2014
Last Verified: October 2012