Clinical Trial: Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: USFetus Randomized Clinical Trial: Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome

Brief Summary: The investigators hypothesize that treatment of twin-twin transfusion syndrome (TTTS) using sequential laser photocoagulation of communicating vessels (SQLPCV) over the predominant method, selective laser photocoagulation of communicating vessels (SLPCV), may provide vascular stability to the donor fetus. The primary objective is to evaluate the perinatal outcome, specifically, donor intrauterine survival of TTTS managed by SQLPCV vs. SLPCV in a prospective, randomized trial.

Detailed Summary:
Sponsor: University of Southern California

Current Primary Outcome: To compare donor intrauterine survival (alive at birth) for those undergoing SQLPCV vs. SLPCV. [ Time Frame: Birth ]

A comparison of donor survival at birth will be made between subjects assigned to the sequential (SQLPCV) procedure versus those assigned to the selective (SLPCV) procedure.


Original Primary Outcome: Same as current

Current Secondary Outcome: Surgical complications [ Time Frame: 21 post-operative days ]

Original Secondary Outcome: Same as current

Information By: University of Southern California

Dates:
Date Received: April 16, 2014
Date Started: June 2010
Date Completion: February 2020
Last Updated: March 8, 2017
Last Verified: March 2017