Clinical Trial: The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

Official Title: The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes

Brief Summary: To study the association between maternal serum vitamin C concentration in women with preterm premature rupture of membranes (PPROM) and women without PPROM.

Detailed Summary: The micronutrient vitamin C is an effective water soluble antioxidant that scavenges several reactive oxygen species, thus reducing oxidative stress, It also acts as an enzymatic cofactor to the enzymes lysyl hydroxylase and prolyl hydroxylase, which is required for synthesis of hydroxyproline and hydroxylysine, Collagen requires hydroxyproline bridges across the triple helix to provide stability to it, Ascorbic acid also causes down regulation of the metalloproteinase-2 and biosynthesis of collagen where it is required for the formation of triple helical structure of collagen. Thus, ascorbic acid participates in the equilibrium between synthesis and degradation of collagen and this may be critical in reducing the occurrence of preterm PROM.
Sponsor: Ain Shams Maternity Hospital

Current Primary Outcome: relation between serum vitamin C concentration and PPROM [ Time Frame: 6 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Ain Shams Maternity Hospital

Dates:
Date Received: December 15, 2015
Date Started: January 2016
Date Completion: July 2016
Last Updated: December 17, 2015
Last Verified: December 2015