Clinical Trial: Examine the Possible Association of Hepatic CYP3A Activity and the Susceptibility to Femur Head Necrosis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title:

Brief Summary: The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.

Detailed Summary: Femur head necrosis is one of the major side effects of corticosteroid therapy. Since corticosteroids are metabolized by hepatic cytochrome P-450 (CYP) 3A, a low endogenous activity of this enzyme may contribute to the pathogenesis of ONFH. The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.
Sponsor: Osaka City University

Current Primary Outcome:

Original Primary Outcome:

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Original Secondary Outcome:

Information By: Osaka City University

Dates:
Date Received: October 25, 2005
Date Started: November 2002
Date Completion: January 2006
Last Updated: October 16, 2006
Last Verified: October 2006