Clinical Trial: Supplementation of Probiotics and Fruit Fibre to Patients With Fatty Liver

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Supplementation of Probiotics and Fruit Fibre to Patients With Fatty Liver

Brief Summary:

Probiotics and fruit fibre are given for 12 weeks to patients with fatty liver disease.

The hypothesis is that probiotic bacteria and fruit fibre affect the gut microbial composition in a positive manner. The improved ecological system is believed to contribute to improved liver health and thereby counteract fatty liver disease.


Detailed Summary:
Sponsor: Region Skane

Current Primary Outcome: Improved and normalized liver status [ Time Frame: after 12 weeks intervention ]

normalized concentrations of liver enzymes in plasma. Magnetic resonanse imaging (compared to magnetic resonanse imaging before intervention) will also be used in the investigation of improved liver status.


Original Primary Outcome: Same as current

Current Secondary Outcome: Changes in the gut bacterial flora [ Time Frame: after 12 weeks intervention ]

Changes and differences of the gut bacterial flora will be addressed in detail, e.g. changes in concentration of specific bacterial groups (e.g. Lactobacillus) before and after the intervention period.


Original Secondary Outcome: Same as current

Information By: Region Skane

Dates:
Date Received: August 23, 2011
Date Started: August 2011
Date Completion: August 2018
Last Updated: August 5, 2013
Last Verified: August 2013