Clinical Trial: Hyperglycemia in Surgical Infections

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: Studies on Hyperglycemia in Surgical Infections

Brief Summary: The primary purpose of this study is to evaluate two glycemic control regimens on clinical outcome in patients with necrotizing soft tissue infections. Secondary aim is to evaluate the inflammatory and immune responses to the glycemic control regimens.

Detailed Summary: This is a multi-center explanatory trial of strict glycemic control for surgical patients with necrotizing soft tissue infection (NSTI). The primary objective of this study is to verify feasibility of the intervention, provide unbiased and evidence-based estimates of treatment effects, and obtain data needed to design and direct a larger multi-center trial if necessary. The multi-center trial (n >100) will have adequate power to identify a 30% difference in favorable outcome defined as discharge alive from the hospital without an amputation in less than the median number of hospital days. Secondary objectives include evaluation of specific hypotheses relating the intervention to cytokine and neutrophil responses. These preliminary data will provide the basis for future research and grant applications, lend insight into the mechanisms by which hyperglycemia results in adverse effects, and improve outcome through the development of evidence-based therapeutic strategies for patient care.
Sponsor: The University of Texas Health Science Center, Houston

Current Primary Outcome:

  • Infectious Morbidity [ Time Frame: Duration of hospital stay, an average of 2 weeks ]
  • Composite Outcome (Favorable Outcome Defined as Discharge Home, Without an Amputation, in Less Than the Median Hospital Stay for Survivors) [ Time Frame: Duration of hospital stay ]


Original Primary Outcome:

  • Infectious Morbidity
  • Composite Outcome (Favorable Outcome Defined as Discharge Home, Without an Amputation, in Less Than the Median Hospital Stay for Survivors)


Current Secondary Outcome:

  • Organ Failure [ Time Frame: Duration of hospital stay ]
  • Hypoglycemia [ Time Frame: Duration of hospital stay ]


Original Secondary Outcome:

  • Organ Failure
  • Sepsis
  • Hypoglycemia


Information By: The University of Texas Health Science Center, Houston

Dates:
Date Received: July 17, 2006
Date Started: August 2009
Date Completion:
Last Updated: May 2, 2014
Last Verified: May 2014