Clinical Trial: Muscle Relaxation for Short Procedures

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Comparing Intubating Conditions and Patient Satisfaction Using Succinylcholine or Low-dose Rocuronium for Rigid Bronchoscopy: A Randomized Study

Brief Summary: Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application of low-dose rocuronium, reversed by low-dose sugammadex. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM), as well as patient satisfaction for these two muscle relaxants.

Detailed Summary:
Sponsor: Dr. Horst Schmidt Klinik GmbH

Current Primary Outcome: Intubating condition [ Time Frame: After induction of general anaesthesia (after 3-5 minutes) ]

scoring system proposed for Good Clinical Research Practice using the following variables: conditions of inserting rigid bronchoscope, vocal cord position, and coughing


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Fasciculations [ Time Frame: After application of the neuromuscular blocking agent (after 3-5 min) ]

    Fasciculations were graded by the investigator on the following four-point scale

    0 = no fasciculations

    1. = mild, fine fasciculations of the eyes, neck, face or fingers, without limb movement
    2. = moderate fasciculations occurring at more than two sites, or obvious limb movement
    3. = vigorous or severe, sustained and widespread fasciculations in the trunk and limbs
  • Postoperative Myalgia (POM) [ Time Frame: 72 Hours after Intervention ]

    The severity of POM was measured using a four-point scale 0 = no myalgia

    1. = minor pain limited to one area of the body
    2. = muscle pain or stiffness noticed spontaneously by the patient, which may have required analgesic therapy
    3. = generalized, severe, or incapacitating discomfort


Original Secondary Outcome: Same as current

Information By: Dr. Horst Schmidt Klinik GmbH

Dates:
Date Received: July 9, 2013
Date Started: October 2011
Date Completion:
Last Updated: July 16, 2013
Last Verified: July 2013