Clinical Trial: Effects of Cisatracurium on Succinylcholine-induced Fasciculations and Myalgia

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effects of Cisatracurium on Succinylcholine-induced Fasciculations and Myalgia

Brief Summary: The purpose of this study is to investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and postoperative myalgia.

Detailed Summary:

Purpose: To investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and postoperative myalgia.

Methods: Ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02 mg/kg cisatracurium, respectively. General anesthesia was induced 3.5 min later, train of four stimulation was monitored 4.5 min later, succinylcholine 1.5 mg/kg was injected 5 min later, and endotracheal intubation was implemented 6.5 min later. The side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, severity of myalgia at 24 h postoperatively, serum potassium before the induction, at the time of endotracheal intubation, and 5 min after intubation were recorded.


Sponsor: Yangzhou No.1 People's Hospital

Current Primary Outcome: The presence of fasciculations [ Time Frame: After the injection of succinylcholine for 1.5 minutes ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Side effects of the pretreatment of cisatracurium [ Time Frame: At the time of three minutes after the pretreatment of cisatracurium ]
  • The time to maximal depression of twitch [ Time Frame: From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes ]
  • The extent to maximal depression of twitch [ Time Frame: From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes ]
  • The time for twitch recovery to 20% of its control value [ Time Frame: From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes ]
  • The grades of endotracheal intubation [ Time Frame: At intubating time ]
  • The changes of serum potassium [ Time Frame: After entering the operating theater till the anesthesia induction, at intubating, and 5 min after intubation ]
  • Myalgia at 24 hours postoperatively [ Time Frame: At 24 hours postoperatively ]


Original Secondary Outcome: Same as current

Information By: Yangzhou No.1 People's Hospital

Dates:
Date Received: June 10, 2015
Date Started: March 2013
Date Completion:
Last Updated: June 22, 2015
Last Verified: June 2015