Clinical Trial: Studying Genes, Environment, and Prostate Cancer Risk in Patients With or Without Prostate Cancer and Their First-Degree Relatives

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Genetic Susceptibility, Environment & Prostate Cancer Risk

Brief Summary:

RATIONALE: Gathering information about genetic and environmental factors may help doctors learn more about a person's risk for developing prostate cancer.

PURPOSE: This clinical trial is studying genes, environment, and prostate cancer risk in patients with or without prostate cancer and their first-degree relatives.


Detailed Summary:

OBJECTIVES:

  • To evaluate the evidence of familial aggregation for prostate cancer and identify a homogenous subgroup of families with elevated likelihood of aggressive disease ("high familial risk") using a family case-control design.
  • To determine if genetic variation in selected genes involved in reactive oxygen species (ROS) detoxification (e.g., glutathione and superoxide dismutase genes) and the oxidative stress response (e.g., NFE2) are independently or jointly associated with greater mitochondrial DNA damage and increased prostate cancer risk.
  • To determine if dietary intake of ω-3 fatty acids alters the risk of prostate cancer.
  • To determine the association between variation in genes involved in ROS detoxification, oxidative stress response, and prostate cancer risk.

OUTLINE: Probands undergo blood and saliva sample collection for fatty acid, DNA, and polymorphism analyses. Archived blood and tissue samples from probands who previously participated in Dr. Shannon's Diet and Prostate Cancer Risk study are also analyzed. First-degree relatives (FDRs) of probands found to be part of a homogenous high-risk subgroup undergo saliva sample collection for DNA analyses.

Medical records of probands are reviewed for demographics, history and course of disease, and clinical laboratory test results.

All probands and their FDRs complete the "Genetic Risk Easy Assessment Tool Family History of Cancer" and "Diet History and Environmental Risk Factor" questionnaires at baseline. If a proband previously participated on our Diet and Prostate Cancer Risk study, he
Sponsor: Portland VA Medical Center

Current Primary Outcome:

  • Degree of familial aggregation for prostate cancer [ Time Frame: 4th quarter - 2012 ]
  • Association between genetic variations, mitochondrial DNA damage, and prostate cancer risk [ Time Frame: 4th quarter - 2012 ]
  • Association between dietary intake of ω-3 fatty acids and prostate cancer risk [ Time Frame: 4th quarter - 2012 ]
  • Association between variation in genes involved in reactive oxygen species detoxification, oxidative stress response, and prostate cancer risk [ Time Frame: 4th quarter - 2012 ]


Original Primary Outcome:

  • Degree of familial aggregation for prostate cancer
  • Association between genetic variations, mitochondrial DNA damage, and prostate cancer risk
  • Association between dietary intake of ω-3 fatty acids and prostate cancer risk
  • Association between variation in genes involved in reactive oxygen species detoxification, oxidative stress response, and prostate cancer risk


Current Secondary Outcome:

Original Secondary Outcome:

Information By: Portland VA Medical Center

Dates:
Date Received: November 11, 2009
Date Started: July 2008
Date Completion:
Last Updated: February 21, 2013
Last Verified: February 2013