Clinical Trial: Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2

Brief Summary: The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to GTN infusion.

Detailed Summary:

Glyceryl trinitrate (GTN) induces migraine attacks indistinguishable from spontaneous attacks in approximately 80% of migraine sufferers. After systemic administration GTN is transformed to nitric oxide (NO). Treatment of spontaneous migraine attacks with an inhibitor of NO is effective in 60% of patients. These data show that NO is involved in both initiation and maintenance of migraine attack.

The consequence of migraine gene mutations on relevant migraine pathways has never been tested. The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to GTN infusion. The project will improve our understanding of the neurobiology of migraine and stimulate development of new treatment targets.

Sponsor: Danish Headache Center

Current Primary Outcome: headache and associated symptoms , blood flow velocity of the middle cerebral artery, diameter of the superficial temporal artery

Original Primary Outcome: Same as current

Current Secondary Outcome: MAP, HR

Original Secondary Outcome: Same as current

Information By: Danish Headache Center

Dates:
Date Received: November 22, 2005
Date Started: April 2005
Date Completion: March 2006
Last Updated: July 31, 2006
Last Verified: November 2005