Clinical Trial: Factor XIII and Pulmonary Embolism in Neurosurgical Patients

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Risk Factors for Perioperative Pulmonary Embolism in Neurosurgical Patients in Respect of Factor XIII Activity

Brief Summary: Two studies (Gerlach et al. 2000; Gerlach et al. 2002) described the impact of factor XIII on the risk of prospective hemorrhage for patients undergoing craniotomy. Since then, factor XIII is measured and substituted in various centers. Few reports support the idea of factor XIII being involved in the formation of deep venous thrombosis and pulmonary embolism. In this prospective observational study, patients undergoing craniotomy for brain tumors or vascular lesions are investigated concerning the incidence of postoperative pulmonary embolism in respect of possible risk factors (factor XIII activity levels, standard coagulation parameters, tumor entity, blood loss).

Detailed Summary:
Sponsor: Ludwig-Maximilians - University of Munich

Current Primary Outcome: Incidence of pulmonary embolisms following Factor XIII substitution [ Time Frame: 38 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Ludwig-Maximilians - University of Munich

Dates:
Date Received: April 16, 2010
Date Started: October 2007
Date Completion: December 2010
Last Updated: April 19, 2010
Last Verified: March 2010