Clinical Trial: The Role of Antibiotics in Full Thickness Skin Graft Survival for Facial Reconstructive Surgery

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: The Role of Antibiotics in Full Thickness Skin Graft Survival for Facial Reconstructive Surgery

Brief Summary:

Antibiotics are sometimes prescribed to patients who have had reconstructive surgery of wounds on their face using skin grafts. But, it is not yet known whether antibiotics improve the healing of skin grafts and reduce the risk of infections after surgery in these patients. It is known that antibiotics, like all medications, have side-effects although these are rare. This research study is designed to show us whether antibiotics improve wound healing or not, so that we may determine if we should continue using antibiotics even if they have side-effects in some patients.

Our hypothesis is that patients treated with post-operative, systemic antibiotics will demonstrate a statistically significant improvement in the survival of their facial full thickness skin grafts compared to patients who are not treated with systemic antibiotics.


Detailed Summary:
Sponsor: University of Michigan

Current Primary Outcome: Graft failure rate [ Time Frame: 1 year ]

The primary outcomes will be graft failure rate where failure is defined as any tissue loss extending beyond the epithelium.


Original Primary Outcome: Same as current

Current Secondary Outcome: Percentage surface area of graft failure [ Time Frame: 1 year ]

The secondary outcomes include the percentage surface area of graft failure, the incidence of post-operative adjunctive procedures related to graft cosmesis and the incidence of revision surgery resulting from graft failure.


Original Secondary Outcome: Same as current

Information By: University of Michigan

Dates:
Date Received: July 29, 2013
Date Started: July 2013
Date Completion: September 2019
Last Updated: May 8, 2017
Last Verified: May 2017