Clinical Trial: Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Clinical Trials in Orofacial Neuralgias

Brief Summary:

This study will evaluate the safety and effectiveness of two drugs-dextromethorphan and topiramate-in treating orofacial (mouth and face) pain. Dextromethorphan, a commonly used cough suppressant, and topiramate, an anti-seizure medicine, block certain receptors on brain and spinal nerve cells that may cause the cells to produce electrical discharges and pain.

Patients 18 years of age and older with oral and facial pain with trigeminal nerve damage and who have had pain daily for at least 3 months may be eligible for this study. Candidates will be screened with a medical history, physical examination, blood tests and psychiatric evaluation. These results will serve as baseline values for participants. Those enrolled in the study will take either dextromethorphan or topiramate in a 2-part study as follows:

Dextromethorphan

In Part 1, patients will take dextromethorphan and lorazepam (a commonly used anti-anxiety drug) separately in two 6-week periods. (Lorazepam is used in this study as an "active placebo" for comparison with dextromethorphan. An active placebo is a drug that does not work for the problem being studied but whose side effects are like those of the test drug.) They will take dextromethorphan for 4 weeks to determine the maximum tolerated dose (the highest dose that does not cause troubling side effects) and will stay on that dose for the remaining 2 weeks. Then they will repeat this process with lorazepam. Patients who respond to either drug may continue with Part 2 of the study, which compares these two drugs four more times to confirm the response seen in Part 1. In Part 2, the maximum tolerated dose will be determined in a 2-week period and that dose will be continued for another 2 weeks. This procedure will be repeated eight times. Throughout the

Detailed Summary: Some of the clinical features of trigeminal and other facial neuralgias suggest that these painful disorders may be associated with sensitization of central nervous system neurons. Laboratory evidence has shown that central sensitization can be produced and maintained by excitatory amino acids (e.g. glutamate) acting on neurons at NMDA and AMPA/kainate receptor sites. Given this information, and the need for more effective treatments of orofacial neuropathic pain syndromes, two possible candidates worthy of study are 1) dextromethorphan, an NMDA receptor antagonist and 2) topiramate, an anticonvulsant drug with AMPA/kainate receptor blocking activity. Thus, the purpose of this study is to evaluate the efficacy and safety of topiramate (TPM) or high-dose dextromethorphan (DM) versus placebo in the treatment of pain in patients with trigeminal neuralgia (TN) and other orofacial neuropathic pain syndromes. We propose two 6 month studies respectively evaluating dextromethorphan (60 patients; at least 20 with TN, 20 with definite trigeminal nerve pathology and 20 with likely trigeminal nerve pathology) and topiramate (40 patients; at least 20 with TN, 20 with definite trigeminal nerve pathology). These will be double-blind randomized crossover designs comparing high-dose dextromethorphan (DM) versus lorazepam (LOR) (as an active placebo) OR topiramate versus inactive placebo. The primary study outcome measure (in both parts) will be overall daily pain assessed by Gracely pain intensity descriptors. Other recorded data will include adverse drug effects, the frequency, severity and duration of pain paroxysms and a questionnaire focusing on daily function (modification of the Brief Pain Inventory).
Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: National Institutes of Health Clinical Center (CC)

Dates:
Date Received: November 3, 1999
Date Started: December 1997
Date Completion: January 2002
Last Updated: March 3, 2008
Last Verified: January 2002