Clinical Trial: Local Moxifloxacin and Povidone Iodine Versus Povidone Iodine Alone as a Prophylaxis Before Eye Operations
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title:
Brief Summary: The hypothesis is that povidone iodine alone is sufficient for sterilization of the lacrimal sac and eye lids before intraocular surgeries. Patients admitted for various intraocular surgeries will be randomly allocated to prophylactic local therapy with either moxifloxacin and povidone iodine or povidone iodine alone before surgery. Lacrimal sac and eye lid cultures will be obtained before the local therapy and just before surgery.
Detailed Summary: Over all 500 patients admitted for various intraocular surgeries will be included in the study. The study will be prospective, double blind, placebo controlled, and randomized. Patients will be randomly allocated to prophylactic local therapy with either moxifloxacin and povidone iodine or povidone iodine alone before surgery. For patients treated with povidone iodine alone a placebo will also be given. Lacrimal sac and eye lid cultures will be obtained before the local therapy and just before surgery. All patients will be followed for 6 weeks for symptoms and signs of infection. Bacterial and fungal culture results will be compared between the 2 groups.
Sponsor: HaEmek Medical Center, Israel
Current Primary Outcome:
- Type and amount of bacterial growth
- Post surgery infections
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: HaEmek Medical Center, Israel
Dates:
Date Received: June 5, 2006
Date Started: June 2006
Date Completion: May 2007
Last Updated: May 31, 2007
Last Verified: March 2007
