Clinical Trial: Comparing the Use of Vitamin c (Ascorbic Acid) in Eye Burn in Subconjunctival Injection to Topical or Oral Treatment.

Study Status: Withdrawn
Recruit Status: Withdrawn
Study Type: Interventional

Official Title: The Effect of Subconjunctival Vitamin c on Recovery Rate and End Result From Eye Burn.

Brief Summary: Eye burns may cause a severe permanent damage. One kind of treatment is the use of vitamin C (Ascorbic acid). This study will compare between subconjunctival topical and/or systemic route of administration and topical and/or systemic administration.

Detailed Summary:

In order to prevent permanent and severe damage to the eye after eye burn early treatment is mandatory. It is well known and published that the use of Vitamin c may contribute to the healing process of such burns, including burns from chemicals or heat. We believe that the route pf administration of the medicine is as important as the kind of medicine and that subconjunctival injection will have better effect and will influence in a favorable manner on the the end result as well as on the time of the healing.

In order to be able to compare between cases we made a new definition of the severity of the burn according to the extension of the damage on the cornea, conjunctiva and limbus, and according to the severity and depth of the ischemia.

In 3 medical centers 3 protocols of treatment and followup will be compared while only in Baruch Pade Medical Center the main route of administration will be subconjunctival on top of the topical treatment.

Sponsor: The Baruch Padeh Medical Center, Poriya

Current Primary Outcome: EXTENSION OF FLORSCEIN PAINT ON THE CORNEA AND CONJUNCTIVA [ Time Frame: BID ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: The Baruch Padeh Medical Center, Poriya

Dates:
Date Received: August 13, 2008
Date Started: July 2009
Date Completion: February 2010
Last Updated: February 28, 2010
Last Verified: February 2010