Clinical Trial: Pancreatic Insufficiency Secondary to Tobacco Exposure

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Pancreatic Insufficiency Secondary to Tobacco Exposure

Brief Summary: Pancreatic insufficiency is a condition in which there is a decrease in the production and release of enzymes made in the pancreas, which causes nutrient malabsorption. There are many chronic diseases that can lead to pancreatic insufficiency. In the early stages of this disease, a patient may not experience any symptoms, and the prevalence of pancreatic insufficiency may be underestimated. Smoking has long been recognized as a cause of disease in many organs in the body. Cigarette smoke causes inflammation and damages tissue, including the pancreas. Studies have shown that smoking is an independent risk factor for pancreatic cancer and chronic pancreatitis. It has also been shown that the more a person smokes, the worse his disease will be. Additionally, there are studies that show that smokers have nutritional deficiencies. There are observational and retrospective studies that suggest that pancreatic insufficiency may also be caused by smoking. However, this has not been established, and the relationship has not been examined in a controlled manner. This study examines the relationship between smoking and pancreatic insufficiency in patients who do not have other pancreatic diseases.

Detailed Summary:
Sponsor: Emory University

Current Primary Outcome: pancreatic insufficency [ Time Frame: 1-2 weeks after provision of stool specimen ]

The primary outcome is presence or absence of pancreatic insufficiency as determined by fecal elastase-1 measurement


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Emory University

Dates:
Date Received: July 24, 2013
Date Started: May 2013
Date Completion:
Last Updated: November 13, 2013
Last Verified: November 2013