Clinical Trial: Longitudinal Study for Relapsing Polychondritis

Study Status: RECRUITING
Recruit Status: RECRUITING
Study Type: OBSERVATIONAL

Official Title: Longitudinal Study for Relapsing Polychondritis

Brief Summary: Relapsing polychondritis (RP) is a rare systemic inflammatory disease characterized by recurrent inflammation of cartilage including ears, nose, tracheobronchial tree, chest wall and joints.
Less commonly, it can cause inflammation of eyes, vasculature, nervous system, skin and inner ear.
The purpose of this study is to study the pathogenesis of RP.

Detailed Summary:

Relapsing polychondritis (RP) is a rare systemic inflammatory disease characterized by recurrent inflammation of cartilage including ears, nose, tracheobronchial tree, chest wall and joints.
Less commonly, it can cause inflammation of eyes, vasculature, nervous system, skin and inner ear.
There is variability in organ-system involvement and the disease course is relapsing making the diagnosis challenging.
Delay in diagnosis can lead to end-organ damage and significant morbidity and mortality.
There are no biomarkers or blood tests that can assist with assignment of a diagnosis.

Development of this longitudinal cohort and multicenter approach offers the potential to generate new insights and generate new questions regarding the immunology of the disease.
Attainment of a better understanding of the mechanisms and trajectory of inflammation may yield insights into potential new diagnostic and treatment strategies.

Study visits will occur every 6 months, or annually.
Blood and urine collection will occur at every visit.
A physical exam and medical and medication history will at every visit; also, participants will be asked to complete several questionnaires to assess disease activity, health status, and tobacco, alcohol, and drug use.

Sponsor: University of Pennsylvania

Current Primary Outcome: To study the manner of development of disease in patients affected with relapsing polychondritis.

Original Primary Outcome: To study the manner of development of disease in patients affected with relapsing polychondritis.

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Pennsylvania

Dates:
Date Received: May 11, 2021
Date Started: February 26, 2021
Date Completion: January 01, 2024
Last Updated: March 23, 2023
Last Verified: March 01, 2023