Clinical Trial: The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women

Study Status: Active, not recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women

Brief Summary: The purpose of the study is to examine the effects of different exercise intensity training programs upon blood vessel function and circulating blood cells involved in blood vessel repair in young women. The long term effects of exercise may be beneficial to cardiovascular health and it is important to understand the training methods that are the most beneficial. In particular we aim to determine if brief maximal exercise improves the function and stiffness of blood vessels and enhance blood vessel repair. Two methods of exercising are being compared, exercise bouts involving intermittent exercise and exercise completed all at once, but at a very high intensity.

Detailed Summary:
Sponsor: University of Leeds

Current Primary Outcome: Maximal oxygen uptake [ Time Frame: 4 weeks ]

A measure of aerobic capacity determined during an incremental exercise test to volitional fatigue on an exercise ergometer.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Heart rate variability [ Time Frame: 4 weeks ]
  • Endothelial progenitor cell function [ Time Frame: 4 weeks ]
    measures of in vitro cell migratory ability, adhesion and classification of endothelial progenitor cells
  • Flow mediated dialtion [ Time Frame: 4 weeks ]
    Measure of vascular endothelial function determined non-invasively at the brachial artery
  • Arterial stiffness [ Time Frame: 4 weeks ]
    The stiffness of the carotid artery is measured using a combination of ultrasound imaging and non-invasive blood pressure measurements. Lower degrees of stiffness are more favourable.
  • Circulating angiogenic cell numbers [ Time Frame: 4 weeks ]
    These cells are involved in vascular repair and proliferation and may be measured using flow cytometric methods. Specifically cells with CD34 and CD309 antigens are enumerated.
  • Endothelial progenitor cell function [ Time Frame: 4 weeks ]
    Measure of in vitro migratory, adhesion and classification of endothelial progenitor cells.


Original Secondary Outcome: Same as current

Information By: University of Leeds

Dates:
Date Received: March 11, 2011
Date Started: March 2011
Date Completion: November 2012
Last Updated: March 11, 2011
Last Verified: March 2011