Clinical Trial: Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF)

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Heart Function, Body Composition and Metabolic Status

Brief Summary: Purpose: The purpose of the study is to examine if treatment with liothyronine increases left ventricular ejection fraction (LVEF) in patients with stable, chronic heart failure.

Detailed Summary: The patients are examined 3 times. At baseline, after 3 months and after 6 months.After the examination is performed, they begin the study medication while admitted at Dept. of Cardiology, Herlev Hospital, for cardiac monitoring.
Sponsor: Jens Faber

Current Primary Outcome: LVEF [ Time Frame: 3 months ]

The effect of liothyronine treatment in low dose in 3 months on LVEF.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Body composition [ Time Frame: 3 months ]
    The effect of 3 months low dose liothyronine treatment on body composition in patients with heart failure.
  • Quality of Life [ Time Frame: 3 months ]
    The effect of 3 months low dose liothyronine treatment on quality of life assessed by SF-36 and Minnesota Living with Heart Failure questionnaires in patients with heart failure.
  • YKL-40, YNF-alpha, hsCRP and IL-6 [ Time Frame: 3 months ]
    The effect of 3 months low dose liothyronine treatment on low grade inflammation assessed by measurement of pro-inflammatory markers in patients with heart failure.
  • RBP 4, HBA1C, adiponectin (high and low weight), glucose and HOMA-1 [ Time Frame: 3 months ]
    The effect of 3 months low dose liothyronine treatment on metabolic status in patients with heart failure.
  • GDF 8, SHBG, CK and PINP [ Time Frame: 3 months ]
    The effect of 3 months low dose liothyronine treatment on the extrathyroidal thyroid effect in patients with heart failure.
  • NT-proBNP, EDV and ESV [ Time Frame: 3 months ]
    The effect of 3 months low dose liothyronine treatment on heart function in patients with heart failure.


Original Secondary Outcome: Same as current

Information By: Herlev Hospital

Dates:
Date Received: November 25, 2011
Date Started: July 2011
Date Completion:
Last Updated: February 25, 2014
Last Verified: February 2014