Clinical Trial: The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis
Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional
Official Title: The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis
Brief Summary: The purpose of this study is to determine the role of hypoxia inducible factor (HIF)-2a on the production of inflammatory cytokines that lead to reflux esophagitis.
Detailed Summary: Reflux esophagitis is thought to be caused by gastric acid that refluxes into the esophagus, causing injury. Newer data suggest that reflux of gastric juice into the esophagus stimulates HIF-2a, which increases production of inflammatory cytokines. These cytokines are thought to lead to reflux esophagitis. The investigators plan to study the relationship of HIF-2a to inflammatory cytokines in patients with known gastroesophageal reflux disease and reflux esophagitis.
Sponsor: Dallas VA Medical Center
Current Primary Outcome: change in esophageal inflammation from baseline to 14 days [ Time Frame: day 0 and day 14 ]
Original Primary Outcome: Same as current
Current Secondary Outcome: change in HIF-2a levels from baseline to 14 days [ Time Frame: day 0 and day 14 ]
Original Secondary Outcome: Same as current
Information By: Dallas VA Medical Center
Dates:
Date Received: November 16, 2012
Date Started: February 2013
Date Completion: March 2017
Last Updated: August 1, 2016
Last Verified: August 2016