Clinical Trial: The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis

Brief Summary: The purpose of this study is to determine the role of hypoxia inducible factor (HIF)-2a on the production of inflammatory cytokines that lead to reflux esophagitis.

Detailed Summary: Reflux esophagitis is thought to be caused by gastric acid that refluxes into the esophagus, causing injury. Newer data suggest that reflux of gastric juice into the esophagus stimulates HIF-2a, which increases production of inflammatory cytokines. These cytokines are thought to lead to reflux esophagitis. The investigators plan to study the relationship of HIF-2a to inflammatory cytokines in patients with known gastroesophageal reflux disease and reflux esophagitis.
Sponsor: Dallas VA Medical Center

Current Primary Outcome: change in esophageal inflammation from baseline to 14 days [ Time Frame: day 0 and day 14 ]

inflammation of the squamous esophageal mucosa will be measured at baseline and at 14 days


Original Primary Outcome: Same as current

Current Secondary Outcome: change in HIF-2a levels from baseline to 14 days [ Time Frame: day 0 and day 14 ]

Amount of HIF-2a present will be measured at baseline and at 14 days


Original Secondary Outcome: Same as current

Information By: Dallas VA Medical Center

Dates:
Date Received: November 16, 2012
Date Started: February 2013
Date Completion: March 2017
Last Updated: August 1, 2016
Last Verified: August 2016