Clinical Trial: Non-invasive Prediction of Esophageal Varices in Liver Cirrhosis: A Multicenter Observational Study

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Non-invasive Prediction of Esophageal Varices in Liver Cirrhosis: A Multicenter Observational Study

Brief Summary: Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding.

Detailed Summary: Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding. The investigators' recent systematic review evaluated the diagnostic accuracy of APRI, AAR, FIB-4, FI, King, Lok, Forns, and FibroIndex scores in predicting the presence of esophageal varices in liver cirrhosis. However, their diagnostic accuracy was low to moderate. Further study is warranted to establish a reliable score to predict the presence of high-risk esophageal varice in liver cirrhosis.
Sponsor: General Hospital of Shenyang Military Region

Current Primary Outcome: Correlation of biochemical data with esophageal varices in liver cirrhosis [ Time Frame: 18 months ]

The investigators firstly calculated the significant factors associated with the presence of esophageal varices, and then developed a score to predict the presence of esophageal varices in liver cirrhosis.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: General Hospital of Shenyang Military Region

Dates:
Date Received: October 30, 2015
Date Started: December 2015
Date Completion: December 2017
Last Updated: August 8, 2016
Last Verified: August 2016