Clinical Trial: Trial of Monthly Versus Bi-weekly Endoscopic Variceal Ligation for the Prevention of Esophageal Variceal Rebleeding

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Trial of Monthly Versus Bi-weekly Endoscopic Variceal Ligation for the Prevention of Esophageal Variceal Rebleeding

Brief Summary: Many physicians suggest repeating EVL every 1-2 weeks until esophageal varices are obliterated to prevent variceal rebleeding， however, the evidences supporting the efficacy of EVL intervals of 1-2 weeks are insufficient.This randomized controlled study was conducted in order to compare the long-term results of EVL when performed at two different results from monthly and bi-weekly treatments.

Detailed Summary: Endoscopic variceal ligation (EVL) is a safe and simple procedure now being used on a widening scale. A lot of patients who undergo endoscopic treatment for esophageal varices eventually require additional treatment for recurrent varices. Many physicians suggest repeating EVL every 1-2 weeks until esophageal varices are obliterated to prevent variceal rebleeding， however, the evidences supporting the efficacy of EVL intervals of 1-2 weeks are insufficient.This randomized controlled study was conducted in order to compare the long-term results of EVL when performed at two different results from monthly and bi-weekly treatments.
Sponsor: West China Hospital

Current Primary Outcome: variceal rebleeding rate [ Time Frame: 2 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • gastrointestinal rebleeding rate [ Time Frame: 2 years ]
  • variceal obliteration rate [ Time Frame: 2 years ]
  • number of sessions required to abstain variceal obliteration [ Time Frame: 2 years ]
  • adverse events [ Time Frame: 2 years ]
  • mortality [ Time Frame: 2 years ]


Original Secondary Outcome:

  • gastrointestinal rebleeding rate [ Time Frame: 2 years ]
  • variceal obliteration rate [ Time Frame: 2 years ]
  • sessions required to abstain variceal obliteration [ Time Frame: 2 years ]
  • adverse events [ Time Frame: 2 years ]
  • mortality [ Time Frame: 2 years ]


Information By: West China Hospital

Dates:
Date Received: March 19, 2016
Date Started: March 2016
Date Completion: February 2018
Last Updated: April 4, 2017
Last Verified: April 2017