Clinical Trial: Reduction in Symptomatic Esophageal Stricture Formation

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Reduction in Symptomatic Esophageal Stricture Formation Post-two Stage Complete Barrett's Excision for High Grade Dysplasia or Early Adenocarcinoma With Short-term Steroid

Brief Summary: Complete endoscopic resection of early neoplastic BE is a curative procedure. However, a significant proportion of patients develop symptomatic esophageal strictures following CBE, and this limits the technique, particularly for circumferential and longer segment disease. Oral steroid therapy may reduce stricture formation; thereby allowing CBE to be performed with minimal associated morbidity.

Detailed Summary: The main objective of the proposed randomized trial is to compare the rate of symptomatic oesophageal strictures in patients receiving placebo versus oral prednisone.
Sponsor: Florida Hospital

Current Primary Outcome: stricture formation [ Time Frame: 98 weeks ]

Primary outcome measure is the rate of symptomatic esophageal stricture formation.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Florida Hospital

Dates:
Date Received: January 15, 2014
Date Started: March 2014
Date Completion:
Last Updated: February 13, 2017
Last Verified: February 2017