Clinical Trial: Prospective Study on the Feasibility and Effectiveness of Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Prospective Study on the Feasibility and Effectiveness of Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders

Brief Summary: rimary spastic esophageal motility disorders, though uncommon, induce significant symptoms to patients including dysphagia, spastic chest pain, regurgitation as well as heartburn. The commonest causes of spastic esophageal motility disorders included Achalasia, hypertensive lower esophageal sphincter (LES), Nutcracker esophagus and Diffuse esophageal spasm (DES). Majority of these diseases were diagnosed by manometry. Achalasia is the most common primary esophageal motility disorder in which the LES failed to relax with increased pressure. Currently the standard treatment for Achalasia and spastic motility disorders is Laparoscopic Myotomy. The development of Natural Orifices Transluminal Endoscopic Surgery (N.O.T.E.S.) has lead to a new way to perform myotomy - Peroral Endoscopic Myotomy (P.O.E.M.). Basically, through mucosal incision, a submucosal tunnel is created after identification of the level of gastroesophageal junction. Myotomy will be performed with endoscopic instruments and the entrance site will be closed with clips.

Detailed Summary:
Sponsor: Chinese University of Hong Kong

Current Primary Outcome: Relief of Dysphagia [ Time Frame: 4 weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Complication [ Time Frame: 30 days ]

Original Secondary Outcome: Same as current

Information By: Chinese University of Hong Kong

Dates:
Date Received: February 1, 2012
Date Started: July 2010
Date Completion:
Last Updated: February 1, 2012
Last Verified: October 2010