Clinical Trial: Esophageal Atresia: Metaplasia, Barrett

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Prevalence of Barrett's Esophagus in Adolescents and Young Adults With Esophageal Atresia

Brief Summary: The frequency of Barrett's esophagus (BE) has increased in adults in the last decades, but BE is rare in children. Esophageal atresia (EA), the most common congenital anomaly affecting the esophagus, predisposes the patient to severe and prolonged gastroesophageal reflux disease. Because gastroesophageal reflux disease plays a major role in the development of BE by causing repeated mucosal damage, development of BE is a concern even in children and young adults in this specific population. The aim of this study is to assess the prevalence of BE (gastric and/or intestinal metaplasia) in a population of adolescents/young adults who had been treated for EA in early infancy. All eligible patients received upper gastrointestinal endoscopy under general anesthesia with standardized esophageal staged biopsies. Histological suspicion of metaplasia was confirmed centrally.

Detailed Summary:
Sponsor: University Hospital, Lille

Current Primary Outcome: presence of gastric and / or intestinal metaplasia diagnosed at histology [ Time Frame: during 2 hours of the endoscopy exam ]

Prevalence of Barrett's esophagus (gastric and/or intestinal metaplasia) in adolescents treated for esophageal atresia


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • presence of esophagitis or anomalies at the anastomotic stage diagnosed at histology [ Time Frame: during 2 hours of the endoscopy exam ]
  • evaluation of the nutritional status [ Time Frame: during the single visit scheduled, the day of endoscopy. This periode is corresponding at a day hospitalization (less than 12 hours in the day) ]
  • evaluation of actual symptoms and treatment of gastroesophageal reflux disease [ Time Frame: during the single visit scheduled, the day of endoscopy. This periode is corresponding at a day hospitalization (less than 12 hours in the day) ]
  • evaluation of actual other symptoms (respiratory, dysphagia) [ Time Frame: during the single visit scheduled, the day of endoscopy. This periode is corresponding at a day hospitalization (less than 12 hours in the day) ]


Original Secondary Outcome: Same as current

Information By: University Hospital, Lille

Dates:
Date Received: June 22, 2015
Date Started: February 2010
Date Completion:
Last Updated: July 10, 2015
Last Verified: July 2015