Clinical Trial: Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)

Brief Summary:

The goal of this study is to identify and characterize the genetic loci causing idiopathic talipes equinovarus (clubfoot).

The hypothesis is that a few genes account for a substantial fraction of ITEV and that these genes can be identified in defined populations. Towards this goal, in preliminary studies, Dr. Hecht's group has identified two genes, NAT2 and CASP10, which demonstrate evidence for linkage and association to ITEV.

Detailed Summary:

Blood Collection: For this study, the investigators need to obtain blood samples from members of families in which clubfoot has occurred; more specifically, blood samples from the affected child and both parents. DNA will be extracted from blood samples. The DNA will then be tested to look for genetic factors that cause clubfoot.

Study Questionnaires: As well as the blood samples, the investigators have a short questionnaire for the mother of the child with clubfoot to complete.

Sponsor: University of British Columbia

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of British Columbia

Dates:
Date Received: May 14, 2007
Date Started: August 2004
Date Completion:
Last Updated: March 27, 2014
Last Verified: March 2014