Clinical Trial: Clubfoot DNA Repository
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Clubfoot DNA Repository
Brief Summary: To build a DNA repository to enable participation in ongoing and future Clubfoot genetic linkage studies.
Detailed Summary:
Clubfoot is a birth defect that can occur alone (in isolation) or as a part of a disease like cerebral palsy (CP). Genetic linkage is a research tool in which DNA samples are tested for genetic landmarks (markers) whose location on chromosomes is known. Genes and markers that are physically close to one another on the chromosome are said to be tightly linked than genes and markers that are located far apart. This gives clues of where to search for genes causing isolated clubfoot. If there appears to be a high correlation between family members' inheritance of a particular marker, and their inheritance of the trait being studied (in this case clubfoot), the area of the chromosome near that marker can then be searched for a likely gene which causes the trait. It is hoped that genetic linkage research might eventually result in new or improved ways to determine individuals and families at higher risk for clubfoot and development of new or improved ways to treat clubfoot.
Our research staff will obtain information about each subject and their family called a pedigree. We will then administer a one page questionnaire to the mother(s) of the affected individual(s). This questionnaire will ask about the mother's experiences during pregnancy (e.g. Did she take multivitamins? Did she smoke or drink? etc.)
Each of the study participants (affected and non-affected individuals) will be asked to provide DNA from a blood sample. If collecting a blood sample is not possible we can also obtain DNA by collecting a saliva sample.
Samples for DNA processing will be stored according to the following repository guidelines. Patient/donor-subject information, questionnaires, and consents will be maintained by the orthopaedic research coordinator.
Sponsor: Texas Scottish Rite Hospital for Children
Current Primary Outcome: To identify a gene, or genes, that are associated with isolated clubfoot. [ Time Frame: 10 years ]
Original Primary Outcome: Same as current
Current Secondary Outcome: New or improved ways to determine individuals and families at higher risk for clubfoot and development of new or improved ways to treat clubfoot. [ Time Frame: 10 years ]
Original Secondary Outcome: Same as current
Information By: Texas Scottish Rite Hospital for Children
Dates:
Date Received: January 22, 2008
Date Started: January 2008
Date Completion:
Last Updated: May 5, 2017
Last Verified: May 2017
