Clinical Trial: Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation

Brief Summary:

The overall goal of this study is to open up the promising treatment of repetitive transcranial magnetic stimulation (rTMS), which has been shown to be effective against seizures in patients with surface neocortical foci, to a much larger population of patients with mesial temporal lobe epilepsy (MTLE) and other forms of epilepsy with deep foci, who are not currently considered good rTMS candidates.

The investigators hypothesize that rTMS can modulate the hyperexcitable state in patients with deep seizure foci by targeting its usage to accessible cortical partner regions. In this study the investigators aim 1) to map the functional connectivity of the epileptogenic mesial temporal lobe in patients with medically refractory mesial temporal lobe epilepsy; and 2) to perform a randomized controlled assessment of repetitive transcranial magnetic stimulation protocols applied to specific neocortical targets in mesial temporal lobe epilepsy. The methods used in this study will include magnetic resonance imaging (MRI) of the brain, electroencephalography (EEG), and transcranial magnetic stimulation (TMS).

Detailed Summary:
Sponsor: Beth Israel Deaconess Medical Center

Current Primary Outcome: Seizure frequency [ Time Frame: 12 weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Interictal epileptiform discharge frequency on electroencephalogram [ Time Frame: at 12 week follow-up ]

Original Secondary Outcome: Same as current

Information By: Beth Israel Deaconess Medical Center

Dates:
Date Received: January 8, 2015
Date Started: January 2015
Date Completion:
Last Updated: February 4, 2017
Last Verified: February 2017