Clinical Trial: CBT Versus Selective Serotonin Reuptake Inhibitor For Treatment Of Depression In Temporal Lobe Epilepsy Patients

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Treatment Of Depression In Patients With Temporal Lobe Epilepsy: Comparative Study Of Cognitive Behavioral Therapy Vs. Selective Serotonin Reuptake Inhibitors

Brief Summary: The aim of the study is to compare the effect of group-cognitive-behavioral therapy (CBT)versus treatment as usual with the selective serotonin reuptake inhibitor sertraline, in patients with diagnosis of temporal lobe epilepsy (TLE) and depressive disorder.

Detailed Summary:

patients with temporal lobe epilepsy and depression will be enrolled into one of two treatment modality. The first group will receive 12 group cognitive behavioral sessions. CBT is a psychotherapy focused on the recognition and change of distorted thoughts and maladaptive behaviors.

The second group will receive treatment with the selective serotonin reuptake inhibitor sertraline or citalopram for 12 weeks. This antidepressant is wide used to treat depression in patients with TLE.


Sponsor: El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez

Current Primary Outcome: Change in Beck Depression Inventory score [ Time Frame: baseline, 6 weeks and 12 weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Quality of Life in Epilepsy Scale [ Time Frame: baseline, 6 weeks and 12 weeks ]
    the quality of life in epilepsy scale measures the patients perceived quality of life. Higher score indicates better quality of life. score goes from 0 to 100
  • Hospital anxiety and depression scale (HADS) [ Time Frame: baseline, 4weeks and 12 weeks ]
    the HADS measures severity of symptoms of anxiety and depression. Lower scores indicates less symptoms


Original Secondary Outcome: Same as current

Information By: El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez

Dates:
Date Received: October 7, 2014
Date Started: August 2014
Date Completion:
Last Updated: March 27, 2015
Last Verified: October 2014