Clinical Trial: Transcranial Magnetic Stimulation and Anti-epileptic Effect: Optimization and Evaluation With Electrophysiology.

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Transcranial Magnetic Stimulation and Anti-epileptic Effect: Optimization and Evaluation With Electrophysiology.

Brief Summary: Epileptic disease is characterised by enhanced brain excitability. Low frequency repetitive transcranial magnetic stimulation (rTMS) can be an effective treatment for refractory frontal epilepsy. Thought, physiological mechanisms of its effectivity are still unknown. It is yet possible to evaluate cortical excitability and inhibition with TMS-coupled electromyography before and after rTMS sessions ; this could provide clues for basic mechanisms of rTMS effects on the epileptic brain. We assume that rTMS decrease brain excitability by improving brain inhibition. Such an information could help for treating patients with both pharmacological and non-pharmacological methods.

Detailed Summary:
Sponsor: University Hospital, Strasbourg, France

Current Primary Outcome: Electrophysiological parameters for cortical excitability measured just before and after rTMS, 4 hours later and 24 hours later.

Original Primary Outcome: Same as current

Current Secondary Outcome: Clinical efficacity on seizure intensity and frequency.

Original Secondary Outcome: Same as current

Information By: University Hospital, Strasbourg, France

Dates:
Date Received: September 28, 2006
Date Started: May 2006
Date Completion:
Last Updated: August 29, 2011
Last Verified: August 2011