Clinical Trial: Treatment With High Dose Methotrexate in Patients With Eosinophilic Fasciitis
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Treatment With High Dose Methotrexate in Patients With Eosinophilic Fasciitis
Brief Summary: Evaluate the effect of high dose MTX on skin induration in patients with eosinophilic fascia.
Detailed Summary: Eosinophilic fasciitis (EF)is a fibrosing skin disorder extensively involving the deep fascia. The aim of this pilot study is to evaluate the effect of high dose MTX on skin induration in patients with EF. In addition, we study the effect of this treatment on joint mobility, peripheral blood eosinophilia, functional ability, and pulmonary function. By administering high dose MTX intravenously every four weeks with a Leukovorin rescue, we hope to induce a more pronounced and sustained effect on the involved skin with less (long-lasting) side effects.
Sponsor: Radboud University
Current Primary Outcome: Efficacy is evaluated after 6 months. [ Time Frame: December 2008 ]
Original Primary Outcome: Efficacy is evaluated after 6 months.
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Radboud University
Dates:
Date Received: February 28, 2007
Date Started: October 2006
Date Completion:
Last Updated: August 10, 2011
Last Verified: July 2010