Clinical Trial: Fibrostenotic Eosinophilic Esophagitis: Assessment Tools

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Fibrostenotic Eosinophilic Esophagitis: Endoscopic, Histologic and Molecular Characterization and Evaluation of Clinical Assessment Tools

Brief Summary: This protocol addresses a central hypothesis that fibrostenotic Eosinophilic Esophagitis (EoE) is characterized by abnormal esophageal structure and compliance compared to non fibrostenotic EoE and that distinctive cellular and molecular profiles predict the fibrostenotic phenotype. This study aims to define and assess the changes that occur in the structure and dynamics of the esophageal wall in pediatric Eosinophilic Esophagitis along with characterizing the histologic and molecular patterns in fibrostenotic EoE.

Detailed Summary:
Sponsor: University of Colorado, Denver

Current Primary Outcome: Stricture, as measured by endoscopic assessment [ Time Frame: Day 1 ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Decreased esophageal distensibility, as determined by EndoFlip [ Time Frame: Day 1 ]

Original Secondary Outcome: Same as current

Information By: University of Colorado, Denver

Dates:
Date Received: September 16, 2014
Date Started: December 2014
Date Completion: January 2018
Last Updated: November 16, 2016
Last Verified: November 2016