Clinical Trial: Intestinal Permeability in Response to Treatment in Eosinophilic Esophagitis Patients

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Determination of Intestinal Permeability and Response to Treatment in Patients With Eosinophilic Esophagitis

Brief Summary: Do patient's with eosinophilic esophagitis have increased small intestinal permeability and if this changes in response to topically administered esophageal steroids?

Detailed Summary:

Eosinophilic esophagitis is an allergy mediated disease in which antigens exposed to the gastrointestinal tract trigger a combined immediate hypersensitivity.

The investigators anticipate that patients with active eosinophilic esophagitis will have increased intestinal permeability on urine collection of sugars. The investigators are not sure whether these findings will be found in patients who have been successfully treated with topical esophageal steroids. Improvement in intestinal permeability would be perceived as indicating that esophageal disease drives the intestinal permeability. Lack of improvement would indicate that eosinophilic esophagitis is a more systemic disease in which increased small bowel permeability is a marker or perhaps important driver of the disease.

Sponsor: Mayo Clinic

Current Primary Outcome: To assess patients gastrointestinal symptoms in patients with EoE by means of standard validated questionnaires [ Time Frame: 30 days ]

Original Primary Outcome: Same as current

Current Secondary Outcome: To determine if patients with eosinophilic esophagitis have increased small intestinal permeability and if this changes in response to topically administered esophageal steroids. [ Time Frame: 2 hours ]

Original Secondary Outcome: Same as current

Information By: Mayo Clinic

Dates:
Date Received: July 10, 2012
Date Started: August 2012
Date Completion:
Last Updated: June 20, 2014
Last Verified: June 2014