Clinical Trial: Intestinal Failure in Necrotising Enterocolitis

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Intestinal Failure in Necrotising Enterocolitis

Brief Summary:

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disorder with high morbidity and mortality (20-40%), affecting predominantly premature neonates. NEC continues to present a diagnostic challenge to clinicians. The initial clinical manifestations of NEC are non-specific and indistinguishable from other gastrointestinal disorders and sepsis.

The first goal of this study is to find and evaluate tests to diagnose NEC at an early stage. For the development of new diagnostic markers, the investigators require knowledge of pathophysiological processes that underlie NEC, which still remain unclear. Therefore, the second goal of this study is to elucidate the etiology of NEC. Furthermore, understanding of the pathophysiology of NEC can offer the possibility to develop new therapeutical treatments.

Detailed Summary:
Sponsor: Maastricht University Medical Center

Current Primary Outcome: Urinary I-FABP [ Time Frame: Within the first 30 days (plus or minus 3 days) after clinical suspicion of NEC ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Maastricht University Medical Center

Dates:
Date Received: September 21, 2011
Date Started: September 2004
Date Completion: September 2016
Last Updated: December 17, 2013
Last Verified: December 2013