Clinical Trial: Prevention of Acute Radiation Enteritis With Glutamine

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Efficacy of Glutamine in the Prevention of Acute Radiation Enteritis Among Patients Treated With Radiation of Abdomen and Pelvis.

Brief Summary: Ionizing radiation has cytotoxic effects, and is commonly used as treatment for neoplasm. A common adverse effect of radiation is acute diarrhoea. Glutamine is an aminoacid with antioxidant effects that can protect tissues of damage dued to radiation. The investigators designed a randomized, double-blind trial phase III to study if glutamine prevents acute radiation enteritis.

Detailed Summary:
Sponsor: Castilla-León Health Service

Current Primary Outcome: Number of patients with acute radiation enteritis [ Time Frame: 2 months ]

Original Primary Outcome: Reduction of acute radiation enteritis [ Time Frame: 2 months ]

Current Secondary Outcome: Reduction in inflammatory markers and oxydative stress [ Time Frame: 2 months ]

Original Secondary Outcome: Same as current

Information By: Castilla-León Health Service

Dates:
Date Received: January 22, 2009
Date Started: January 2009
Date Completion:
Last Updated: May 24, 2011
Last Verified: January 2009