Clinical Trial: Blockade of Vascular Potassium Channels During Human Endotoxemia
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Blockade of Vascular Potassium Channels During Human Endotoxemia
Brief Summary: Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.
Detailed Summary:
Sponsor: Radboud University
Current Primary Outcome:
- Hemodynamics [ Time Frame: 24 hrs after LPS administration ]
- Markers of Inflammation [ Time Frame: 24 hrs after LPS administration ]
- Cytokines [ Time Frame: 24 hrs after LPS administration ]
- Markers of Renal Injury [ Time Frame: 24 hrs after LPS administration ]
- Inducible NO synthase expression [ Time Frame: 24 hrs after LPS administration ]
- NO-metabolites [ Time Frame: 24 hrs after LPS administration ]
- Mediators of Vascular reactivity [ Time Frame: 24 hrs after LPS administration ]
- Sensitivity to norepinephrine [ Time Frame: 24 hrs after LPS administration ]
Original Primary Outcome:
- Hemodynamics
- Markers of Inflammation
- Cytokines
- Markers of Renal Injury
- Inducible NO synthase expression
- NO-metabolites
- Mediators of Vascular reactivity
- Sensitivity to norepinephrine
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Radboud University
Dates:
Date Received: September 13, 2005
Date Started: January 2003
Date Completion:
Last Updated: October 16, 2008
Last Verified: April 2008