Clinical Trial: Blockade of Vascular Potassium Channels During Human Endotoxemia

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Blockade of Vascular Potassium Channels During Human Endotoxemia

Brief Summary: Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.

Detailed Summary:
Sponsor: Radboud University

Current Primary Outcome:

  • Hemodynamics [ Time Frame: 24 hrs after LPS administration ]
  • Markers of Inflammation [ Time Frame: 24 hrs after LPS administration ]
  • Cytokines [ Time Frame: 24 hrs after LPS administration ]
  • Markers of Renal Injury [ Time Frame: 24 hrs after LPS administration ]
  • Inducible NO synthase expression [ Time Frame: 24 hrs after LPS administration ]
  • NO-metabolites [ Time Frame: 24 hrs after LPS administration ]
  • Mediators of Vascular reactivity [ Time Frame: 24 hrs after LPS administration ]
  • Sensitivity to norepinephrine [ Time Frame: 24 hrs after LPS administration ]


Original Primary Outcome:

  • Hemodynamics
  • Markers of Inflammation
  • Cytokines
  • Markers of Renal Injury
  • Inducible NO synthase expression
  • NO-metabolites
  • Mediators of Vascular reactivity
  • Sensitivity to norepinephrine


Current Secondary Outcome:

Original Secondary Outcome:

Information By: Radboud University

Dates:
Date Received: September 13, 2005
Date Started: January 2003
Date Completion:
Last Updated: October 16, 2008
Last Verified: April 2008