Clinical Trial: Anti-inflammatory Effects of Enriched Enteral Nutrition During Human Experimental Endotoxemia

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Effect of Enriched Enteral Nutrition on Inflammation and Sub-clinical Organ Dysfunction During Human Endotoxemia

Brief Summary: During sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death. Ideally, the inflammatory response is modulated leading to both adequate protection to invading pathogens as well as limitation of an exuberant immune response. In the last years, experimental evidence has been accumulating that enteral administration of lipid-enriched nutrition attenuates inflammation and preserves organ integrity in several inflammatory models. The current study investigates the immune-modulating potential of enriched enteral nutrition in a human setting of experimental endotoxemia.

Detailed Summary:
Sponsor: Radboud University

Current Primary Outcome: circulating cytokines [ Time Frame: several time points from LPS administration until 24 hours ]

Original Primary Outcome: Same as current

Current Secondary Outcome: markers for sub-clinical organ damage (kidney, endothelium, intestine) [ Time Frame: several time points from LPS administration until 24 h ]

Original Secondary Outcome: Same as current

Information By: Radboud University

Dates:
Date Received: April 7, 2010
Date Started: February 2010
Date Completion:
Last Updated: June 6, 2011
Last Verified: February 2010