Clinical Trial: Targeted PCR and Acute Endophthalmitis

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Contribution of Fast Molecular Bacterial Identification by Real-time PCR in Managing of Postoperative Acute Endophthalmitis

Brief Summary:

Endophthalmitis is a serious eye infection of exogenous origin (post-operational, post-traumatic) or endogenous origin (metastatic). This is a diagnostic and therapeutic emergency.

Each patient suffering from endophthalmitis must have immediately an ocular sampling, an intra ocular injection of antibiotics and a systemic antibiotic cover.

The etiological treatment will be adapted according to the infectious agent.


Detailed Summary:

The main goal of this prospective multi-centre trial is to improve the sensitivity and rapidity of the infectious agent's identification involved in endophthalmitis cases, particularly virulent species (like Staphylococcus aureus, Streptococcus pneumoniae...) from ocular samples with the help of real-time PCR.

This will help the ophthalmologist to be more efficient in accordance with the kind of the bacteria.

Data will also enable to compare both PCR techniques used in this study. The secondary goal of the prospective study is to characterize the resistance of bacterial's species found during acute endophthalmitis with the antibiogram and by the study of resistance genes, to enable to correlate the resistance in vitro with the therapeutic response in vivo and get precious epidemiological data to adapt prophylactic antibiotic.


Sponsor: University Hospital, Grenoble

Current Primary Outcome:

  • Visual acuteness [ Time Frame: 2 minutes ]
    Clinical follow-up of patients
  • Intraocular pressure [ Time Frame: 5 minutes ]
    Clinical follow-up of patients
  • Biomicroscopic exam with the slit lamp [ Time Frame: 3 minutes ]
    State of anterior and posterior segment (back of the eye)


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University Hospital, Grenoble

Dates:
Date Received: July 11, 2016
Date Started: November 2007
Date Completion: August 2016
Last Updated: July 29, 2016
Last Verified: July 2016