Clinical Trial: Endophthalmitis Cultures
Study Status: Terminated
Recruit Status: Terminated
Study Type: Observational
Official Title: Prospective Surveillance of Patients With Endophthalmitis for Multi-antibiotic Resistance (PROSPER) Study
Brief Summary:
The intent of this surveillance study will be to obtain written permission from patients with bacterial endophthalmitis in order to compare sterilization rates of their cultured bacterial isolates to standard therapy (vancomycin and ceftazidime) versus combination therapy with vancomycin, ceftazidime, and moxifloxacin.
Research hypothesis:
- Cultured bacterial isolates will demonstrate faster in vitro sterilization rates with combination treatment (vancomycin, ceftazidime, and moxifloxacin) compared to "standard therapy" with vancomycin and ceftazidime.
- Longitudinal analysis of resistance patterns of cultured isolates will show increasing rates of multi-antibiotic resistance.
Detailed Summary: Adult patients over 18 years of age presenting with endophthalmitis and able to sign consent.
Sponsor: Vanderbilt University
Current Primary Outcome:
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Vanderbilt University Medical Center
Dates:
Date Received: December 19, 2011
Date Started: October 2011
Date Completion:
Last Updated: February 20, 2017
Last Verified: February 2017
