Clinical Trial: Telomeres Evaluation in Endometriosis
Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational [Patient Registry]
Official Title: Telomeres Evaluation in Endometriosis
Brief Summary:
The purpose of the study is to assess the telomere array of different endometriosis tissue and endometrium from women with endometriosis compared to healthy women.
Our hypothesis is that telomere shortening and high telomerase activity will be found in tissues from women with endometriosis.
Detailed Summary:
The purpose of the study is to assess the telomere array of different endometriosis tissue and endometrium from women with endometriosis compared to healthy women. Our hypothesis is that telomere shortening and high telomerase activity will be found in tissues from women with endometriosis, compared to women without endometriosis.
A prospective study that compares telomeres and telomerase levels in different lesions of endometriosis and endometrial tissue of women with endometriosis and healthy women without endometriosis. The study group will consist of women with suspected endometriosis facing surgical treatment and the control group will consist of healthy women facing gynecologic surgery for different indication.
We will sample endometrial tissue in both groups. In the study group we additionally will sample endometriosis lesion.
The samples collected will test for histological diagnosis of endometriosis and verification tests will be done to characterize the telomeres array and telomerase levels and other characteristics for genomic instability such as spontaneous aneuploidy.
expect telomere shortening and high telomerase activity in endometrial tissue and in endometriosis tissue sample, that won't characterize samples from women without endometriosis.
Sponsor: Meir Medical Center
Current Primary Outcome: characterize the telomeres array and telomerase levels and other characteristics for genomic instability such as spontaneous aneuploidy in endometriosis tissue. [ Time Frame: the tissue sample will colect at time of surgery ]
Original Primary Outcome: telomere shortening and high telomerase activity in endometrial tissue and in endometriosis tissue sample [ Time Frame: one year ]
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Meir Medical Center
Dates:
Date Received: March 10, 2013
Date Started: May 2013
Date Completion: February 2015
Last Updated: April 7, 2013
Last Verified: February 2013
