Clinical Trial: Genistein and Endometrial Hyperplasia

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Genistein on Endometrial Hyperplasia

Brief Summary: The aim of this study is to verify the anti-estrogenic activity of Genistein, on the "non atypical endometrial hyperplasia", in premenopausal women.

Detailed Summary:

Although isoflavones alone (example: Genistein) have weak estrogenic effects on endometrial stromal and glandular cells, it was demonstrated, in several research efforts, that in the presence of E2 they act as antiestrogens.

Considered that endometrial hyperplasia is due to strong and extended estrogenic stimulation, not offset by a proportionate amount of progesterone, we suppose that genistein could be therapeutic in these cases inducing a decrease of the hyperplasia and a change from the proliferative to a secretory phase of the endometrium.

Sponsor: University of Messina

Current Primary Outcome: Recovery from endometrial hyperplasia [ Time Frame: 3-6 months ]

Original Primary Outcome: Recovery from endometrial hyperplasia

Current Secondary Outcome: Differential expression of ER-a and ER-b in endometrial specimens [ Time Frame: 6 months ]

Original Secondary Outcome:

Information By: University of Messina

Dates:
Date Received: March 28, 2007
Date Started: January 2007
Date Completion:
Last Updated: December 18, 2008
Last Verified: December 2008