Clinical Trial: Dornase Alfa and Urokinase for Kids With Pleural Empyema

Study Status: Terminated
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Multicentre Randomized Double-Blinded Trial of Intrapleural Dornase Alfa and Urokinase vs Urokinase Alone for Complicated Parapneumonic Effusions in Children

Brief Summary: The purpose of this study is to determine whether intrapleural treatment with Dornase alfa plus Urokinase improves clinical outcome compared to Urokinase alone in children with complicated parapneumonic effusions

Detailed Summary:
Sponsor: Azienda Ospedaliera di Padova

Current Primary Outcome:

  • Duration of hospital stay [ Time Frame: From beginning of intrapleural treatment ]
  • Need for additional surgical procedures [ Time Frame: 3 months ]


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Duration of suction applied to chest drain [ Time Frame: From beginning of intrapleural treatment ]
  • Duration of fever [ Time Frame: From beginning of intrapleural treatment ]
  • Duration of intravenous antibiotic treatment [ Time Frame: From beginning of intrapleural treatment ]


Original Secondary Outcome: Same as current

Information By: Azienda Ospedaliera di Padova

Dates:
Date Received: July 16, 2007
Date Started: October 2007
Date Completion: October 2009
Last Updated: May 9, 2008
Last Verified: May 2008