Clinical Trial: The Role of Fat Emboli in the Trauma Inflammatory Response
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: The Role of Fat Emboli in the Trauma Inflammatory Response
Brief Summary: This is an observational study designed to investigate the role of fat emboli in patients who are undergoing a tibial or femoral fracture procedure in the operating room. The purpose of this study is to obtain samples of bone marrow and blood during tibial or femoral fracture procedures to understand the inflammatory response.
Detailed Summary: Bone marrow is routinely removed during a tibial or femoral fracture procedure; researchers will take samples for this study from bone marrow that has already been removed as part of this procedure. No additional marrow samples will be taken as part of this research study. Also, researchers will collect blood (about 4 teaspoons) for testing inflammatory response and coagulation. Researchers may need to insert an additional line to collect your blood.
Sponsor: Poudre Valley Health System
Current Primary Outcome: Inflammatory Response [ Time Frame: One day ]
Samples will be tested using proteomic and metabolomic assays from samples of bone marrow reamed during intramedullary (IM) femoral nailing.
Blood samples drawn at the time of IM nailing will be tested to determine if clinically relevant amounts of marrow containing these inflammatory mediators are released into the bloodstream.
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Poudre Valley Health System
Dates:
Date Received: February 3, 2014
Date Started: November 2012
Date Completion:
Last Updated: July 22, 2015
Last Verified: July 2015
