Clinical Trial: Cognition Following Computer Assisted Total Knee Arthroplasty

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Cognition Following Computer Assisted Total Knee Arthroplasty: A Prospective Cohort Study

Brief Summary: A significant number of patients experience postoperative cognitive changes following total joint arthroplasty. Among other causes, the mental status change may be the result of fat and bone marrow debris embolization. We hypothesized that the use of computer assisted total knee arthroplasty, which does not utilize intramedullary alignment rods, would produce less fat and bone marrow debris embolization and, hence, fewer mental status changes.

Detailed Summary:

Inclusion criteria

  • Primary, cemented knee arthroplasty
  • Unilateral or bilateral TKA

Exclusion criteria

  • Patient is unable to speak English
  • Unable to read and write
  • Patient with history of psychiatric disorders (Depression, Schizophrenia, anxiety, bipolar dis.)
  • Patients with history of IV drug abuse
  • Previous history of dementia
  • Patients on mental status changing medications

Sponsor: Rothman Institute Orthopaedics

Current Primary Outcome: Folstein Mini Mental State Examination (MMSE) [ Time Frame: 6 Months Post-Operative ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Rothman Institute Orthopaedics

Dates:
Date Received: January 26, 2009
Date Started: July 2005
Date Completion:
Last Updated: April 14, 2009
Last Verified: January 2009