Clinical Trial: Obstructive Sleep Apnoea in Children and Adolescents With Ehlers-Danlos Syndrome

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Obstructive Sleep Apnoea in Children and Adolescents With Ehlers-Danlos Syndrome

Brief Summary:

Ehlers-Danlos Syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. EDS features such as genetically related cartilage defects, craniofacial abnormalities and increased pharyngeal collapsibility have been proposed to cause obstructive sleep apnoea (OSA). There is evidence from studies based on questionnaires that EDS patients might be more frequently affected by OSA and sleep disturbances than the general population. However, the actual prevalence of OSA in children and adolescents with EDS is unknown.

The primary objective of this study is to assess the prevalence of OSA in children and adolescents with EDS (25) compared to a matched control group (25). The secondary objective of this pioneer study is to assess the quality of life in children and adolescents in EDS in comparison to healthy children and adolescents.

Detailed Summary:

Ehlers-Danlos Syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. EDS features such as genetically related cartilage defects, craniofacial abnormalities and increased pharyngeal collapsibility have been proposed to cause obstructive sleep apnoea (OSA). There is evidence from studies based on questionnaires that EDS patients might be more frequently affected by OSA and sleep disturbances than the general population. However, the actual prevalence of OSA in children and adolescents with EDS is unknown.

The primary objective of this study is to assess the prevalence of OSA in children and adolescents with EDS compared to a matched control group. The secondary objective of this pioneer study is to assess the quality of life in children and adolescents in EDS in comparison to healthy children and adolescents.

Sponsor: University of Zurich

Current Primary Outcome: Prevalence of OSA in children and adolescents with EDS [ Time Frame: up to 12 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Quality of life in children and adolescents with EDS [ Time Frame: up to 12 months ]

Original Secondary Outcome: Same as current

Information By: University of Zurich

Dates:
Date Received: March 14, 2016
Date Started: March 2016
Date Completion:
Last Updated: May 12, 2017
Last Verified: May 2017