Clinical Trial: Prediction of Early Pre-eclampsia From Maternal Factors, Biophysical and Biochemical Markers at First Trimester

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Prediction of Early Pre-eclampsia From Maternal Factors, Biophysical and Biochemical Markers at First Trimester

Brief Summary: The aims of this study are to develop algorithms based on a combination of maternal factors, uterine artery PI, MAP and serum biomarkers to estimate patient-specific risks for early Preeclampsia (PE) and to evaluate the screening performance of such algorithms in twins.

Detailed Summary: Preeclampsia (PE) is still a leading cause of fetal and maternal morbidity and mortality with an incidence of 3-5% worldwide. Despite intensive research efforts the pathogenesis of the disease is still unknown but it is likely to be multifactorial.Clinical risk factors traditionally have been used to identify women at high risk of developing preeclampsia,and biophysical factors that may help predict hypertensive disorders of pregnancy.In addition,changes in the serum concentrations of angiogenic and antiangiogenic factors are implied in the pathogenesis of PE and have possible relevance in the diagnosis of the disease.
Sponsor: Shanghai First Maternity and Infant Hospital

Current Primary Outcome: Early preeclampsia [ Time Frame: 1 year ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Selective intrauterine fetal growth restriction [ Time Frame: 1 year ]

Original Secondary Outcome: Same as current

Information By: Shanghai First Maternity and Infant Hospital

Dates:
Date Received: December 9, 2016
Date Started: June 2016
Date Completion: June 2019
Last Updated: December 9, 2016
Last Verified: December 2016